origin of the wrinkle

Regardless of the physiological origin of the wrinkle, the molecular mechanism involved in the aging of the skin is directly related to the conformational changes of the collagen triple helix, the degradation of the elastin polypeptides, and the disorder in the packaging of the lipid matrix of the skin.

That is to say, cutaneous aging, implies a slow decrease of the cellular functions and therefore atrophy of the skin both in the epidermis and in the dermis. However, in recent years it has been shown how the contractions that appear in the membranous septa of connective tissue can be responsible for expression lines. See More at https://foodsocietyx.com/nulante/